Ketamine therapy has shown promise in treating conditions like depression, PTSD, and chronic pain. However, it’s not right for everyone. There are specific criteria that determine whether ketamine therapy is suitable for a person. In this article, we’ll do a deep dive into who is not a good candidate for ketamine therapy and why.
Who Should Avoid Ketamine Therapy
Keep reading to learn more about who should not do ketamine therapy and why ketamine use could cause an issue.
1. People with a History of Substance Abuse
Ketamine, while effective in treating many conditions, can be misused. Individuals with a history of substance abuse, including alcohol or drug addiction, may be more susceptible to the addictive properties of ketamine. Misusing ketamine can derail recovery, making it a poor choice for individuals in recovery or those prone to addiction.
Why It’s an Issue: Ketamine can be habit-forming, and people with addiction history may face difficulties with misuse or dependence. If you or someone you care about has struggled with addiction, ketamine therapy may pose significant risks.

2. Those with Certain Mental Health Disorders
Although ketamine has been shown to help those suffering from depression, anxiety, and PTSD, it can worsen symptoms for individuals with certain mental health conditions. This includes disorders like schizophrenia or other psychotic disorders, where ketamine’s dissociative effects could trigger or exacerbate psychotic episodes.
Why It’s an Issue: Ketamine may lead to confusion, hallucinations, or delusional thinking in people with these disorders. It’s essential for individuals with a history of psychosis to seek other forms of treatment.
3. People with Severe Cardiovascular Conditions
Ketamine therapy stimulates the cardiovascular system, increasing heart rate and blood pressure. So, who is not eligible for ketamine therapy? Individuals with pre-existing heart conditions, such as heart disease, hypertension, or arrhythmias, are all bad candidates for ketamine therapy.
Why It’s an Issue: The stimulant effects of ketamine could worsen cardiovascular issues, leading to complications like heart attacks or strokes. Individuals with severe heart conditions must be cautious before considering ketamine therapy.
4. Pregnant or Breastfeeding Women
The safety of ketamine during pregnancy and breastfeeding is not well-established, so when people ask, “Who is ketamine therapy not for?”, we explain that we don’t recommend it for pregnant or breastfeeding women.
Why It’s an Issue: Ketamine’s effects on fetal development and infants are not fully understood, making it unsafe for pregnant or breastfeeding women. If you’re pregnant, planning to become pregnant, or breastfeeding, it’s important to explore alternative treatment options.
5. Individuals with Liver or Kidney Dysfunction
Ketamine is metabolized by the liver and excreted by the kidneys. Those with liver or kidney dysfunction may not process ketamine properly, which could lead to complications.
Why It’s an Issue: Impaired liver or kidney function can interfere with the metabolism and elimination of ketamine, potentially leading to higher levels of the drug in the body and increased risk of side effects. People with liver or kidney disease should avoid ketamine therapy unless supervised by a healthcare provider.

6. People Taking Certain Medications
Ketamine can interact with various medications, including antidepressants, benzodiazepines, and antipsychotics. These interactions can increase the risk of adverse effects or reduce the effectiveness of ketamine therapy.
Why It’s an Issue: Certain medications, especially those that affect the brain and nervous system, may interfere with ketamine’s action or cause harmful side effects. Always discuss your current medication regimen with your healthcare provider before starting ketamine therapy.
7. Individuals with a History of Seizures
For individuals with a history of seizures or epilepsy, ketamine therapy may not be safe. Ketamine can lower the seizure threshold, making it more likely for someone to experience a seizure.
Why It’s an Issue: If you have a seizure disorder, ketamine could trigger a seizure, especially if you are prone to them. Those with a history of seizures should explore other treatment options.
8. People with Glaucoma
Ketamine can increase intraocular pressure, which may worsen conditions like glaucoma. For those with glaucoma or a family history of the disease, ketamine therapy is typically not recommended.
Why It’s an Issue: Ketamine can aggravate eye pressure, leading to further damage in individuals with glaucoma. It’s important to consult with an eye specialist before considering ketamine if you have any issues with eye health.
Speak with a Healthcare Provider to See if You Are Not a Good Candidate for Ketamine Therapy
San Diego ketamine therapy offers promising benefits for many, but it’s not suitable for everyone. Still wondering who is not a good candidate for ketamine therapy? If you have a history of substance abuse, certain mental health conditions, heart disease, or other health concerns, it’s essential to consult with a healthcare provider before pursuing this treatment. They can evaluate your medical history, medications, and overall health to help determine whether ketamine therapy is suitable for you.
At Experience Structured Living, we’re dedicated to helping you explore whether ketamine therapy is the best option for you or your loved one. If you’re unsure about your eligibility or if other treatment alternatives might be more appropriate, our team is here to offer expert guidance. Reach out today, and we’ll work with you to make an informed decision that’s right for you.
FAQs: Who Is Not a Good Candidate for Ketamine Therapy?
Are there any risks associated with long-term use of ketamine therapy?
Long-term use of ketamine can lead to urinary tract issues and cognitive effects. However, these risks are minimized when used under medical supervision in a therapeutic setting.
Is ketamine safe for people with anxiety disorders?
Ketamine has been effective for many individuals with anxiety disorders, but it may not be suitable for everyone. At Experienced Structured Living, we carefully assess your mental health history to determine if ketamine therapy is right for you. If ketamine isn't suitable, we can provide other treatments for anxiety.
Is ketamine safe for elderly patients?
Elderly patients can undergo ketamine therapy if they are healthy enough to tolerate it. A comprehensive evaluation by a healthcare provider is essential to ensure safety.
Can ketamine therapy be used for chronic pain management?
Yes, ketamine is sometimes used for chronic pain management, but it is important to assess your overall health before starting therapy. If you have heart disease, kidney dysfunction, or a seizure disorder, we can help you explore other treatment options that may be more appropriate.

Dr. Melden earned his Doctorate in Osteopathic Medicine at Philadelphia College Osteopathic Medicine and went to USC Presbyterian Hospital for his residency in Family Medicine. He then completed his Psychiatric residency at the University of California, Irvine and went to UCSD Geropsychiatry pursuing a fellowship. Dr. Melden has over 14 years of experience as a clinician specializing in treating child and adolescent, adult and geriatric clients. He has devoted his life to psychiatry in a variety of different treatment settings including in- patient and out-patient environments. He specializes in the psychiatric evaluation, complementary therapy approaches, and medical management of individuals suffering from mental illness. Currently, he maintains a private practice with Crownview Medical Group in Coronado and Carlsbad, California where he is CEO/President.